RT info:eu-repo/semantics/article
T1 The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2
A1 López Doménech, Guillermo
A1 Serrat, Román
A1 Mirra, Serena
A1 D'Aniello, Salvatore
A1 Somorjai, Ildiko
A1 Abad, Alba
A1 Vitureira, Nathalia
A1 García Arumí, Elena
A1 Alonso Alonso, María Teresa
A1 Rodríguez Prados, Macarena
A1 Burgaya, Ferrán
A1 Andreu, Antoni L.
A1 García-Sancho Martín, Francisco Javier
A1 Trullas, Ramón
A1 García Fernández, Jordi
A1 Soriano, Eduardo
K1 Proteinas mitocondriales
K1 Cerebro - Investigación
AB Brain function requires neuronal activity-dependent energy consumption. Neuronal energy supply is controlled by molecular mechanisms that regulate mitochondrial dynamics, including Kinesin motors and Mitofusins, Miro1-2 and Trak2 proteins. Here we show a new protein family that localizes to the mitochondria and controls mitochondrial dynamics. This family of proteins is encoded by an array of armadillo (Arm) repeat-containing genes located on the X chromosome. The Armcx cluster is unique to Eutherian mammals and evolved from a single ancestor gene (Armc10). We show that these genes are highly expressed in the developing and adult nervous system. Furthermore, we demonstrate that Armcx3 expression levels regulate mitochondrial dynamics and trafficking in neurons, and that Alex3 interacts with the Kinesin/Miro/Trak2 complex in a Ca2 + -dependent manner. Our data provide evidence of a new Eutherian-specific family of mitochondrial proteins that controls mitochondrial dynamics and indicate that this key process is differentially regulated in the brain of higher vertebrates.
PB Macmillan Publishers
SN 2041-1723
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/6344
UL http://uvadoc.uva.es/handle/10324/6344
LA eng
NO Nature Communications, 2012, p. 1-12
NO Producción Científica
DS UVaDOC
RD 22-nov-2024