RT info:eu-repo/semantics/article
T1 Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: Two-Year Follow-up Results
A1 Orozco, Lluis
A1 Munar, Anna
A1 Soler, Robert
A1 Alberca Zaballos, Mercedes
A1 Soler, Francesc
A1 Huguet, Marina
A1 Sentís, Joan
A1 Sánchez García, Ana María de los Ángeles
A1 García-Sancho Martín, Francisco Javier
K1 Osteoartritis - Tratamiento
AB Osteoarthritis is the most prevalentjoint disease and a frequent causeof joint pain, functional loss, and disability(1). Osteoarthritis often becomeschronic, and conventional treatmentshave demonstrated only modest clinicalbenefits, without lesion reversal (2). Cellbasedtherapies have shown encouragingresults in both animal studies and afew human case reports.We have recentlypublished the results of a pilot clinicaltrial designed to assess the feasibilityand safety of osteoarthritis treatmentwith bone marrowYderived mesenchymalstromal cells (MSCs) in 12 patientswith chronic knee pain unresponsiveto conservative treatments and radiologicevidence of osteoarthritis (3). Thepatients were treated with autologousexpanded bone marrow MSCs by intraarticularinjection (40 106 cells), andclinical outcomes, including evaluationsof pain, disability, and quality of life, werefollowed up for 1 year. Articular cartilagequality was assessed by quantitativemagnetic resonance imaging (MRI) T2mapping (3).
PB Lippincott Williams & Wilkins
SN 0041-1337
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/6349
UL http://uvadoc.uva.es/handle/10324/6349
LA eng
NO Transplantation, Junio 2014, vol. 97, n. 11, p. 66-68
NO Producción Científica
DS UVaDOC
RD 22-nov-2024