RT info:eu-repo/semantics/doctoralThesis T1 Estudios lipidómicos en macrófagos. Regulación de los niveles lipídicos por lipinas y su impacto en la biología del macrófago y en procesos inflamatorios A1 Garrido Jiménez, Álvaro A2 Universidad de Valladolid. Escuela de Doctorado K1 Lípidos K1 Lipidomics K1 Lipidómica K1 Metabolomics K1 Lípidos K1 2302 Bioquímica AB This work consists of the description of the lipid profile of different cellular systems, mainly macrophages, in which a key lipid metabolism enzyme, lipin-2, is not present. It has been studied using different techniques, mainly mass spectrometry, how the lack of lipin-2 affects the levels of the different classes of lipids in the cell, as well as the metabolic and functional biological consequences that may be affected, such as membrane fluidity. , cell viability, or phospholipid remodeling. YR 2023 FD 2023 LK https://uvadoc.uva.es/handle/10324/63677 UL https://uvadoc.uva.es/handle/10324/63677 LA spa NO Escuela de Doctorado DS UVaDOC RD 24-nov-2024