RT info:eu-repo/semantics/doctoralThesis
T1 Huella molecular para el diagnóstico diferencial de pacientes sépticos y estimación del riesgo de mortalidad en pacientes con shock posquirúrgico.
A1 Aragón Camino, Marta
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Inmunoglobulinas
K1 Sepsis
K1 Shock
K1 Critical care
K1 Cuidados críticos
K1 32 Ciencias Médicas
AB Sepsis is a common pathology in our day by day hospital work, with a high prevalence in developed countries. Most of the time, sepsis may be complicated by organ dysfunction giving rise to the most severe form: septic shock. This last form could present great clinical similarities to a shock due to other etiology, without any possibility to determine the septic nature facing the same clinical symptoms in our patients. Additionally, shock is recognized as the main death cause in the Intensive Care Units worldwide. Several studies had tried to contribute to a better sepsis diagnosis, through the analysis of the pathophysiology and the immunologic changes at hosts. Whilst, shock molecular mechanisms still represent a huge challenge for our medical services. Therefore, the first aim of our study is to analyze the presence of specific genes expressed in patients with septic shock against shock patients from other etiology, in order to identify specific biomarkers for the first ones.  Moreover, it will attempt to assess the survival probability of shock patients with another shock origin. Nowadays, different scales are used for this purpose, such as APACHE II or SOFA. These systems are based on clinical data, taking no notice of the molecular changes. Besides, clinical decisions are strongly joined to the ICU physicians’ criteria. Hence the development of new clinical tests, which evaluate the molecular changes through the transcription standard analysis, could mean a qualitative leap in mortality prediction in these patients. Thus, our second goal is to identify the gene expression patterns for stratifying patients with postsurgical shock in: high or low mortality risk.
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/63680
UL https://uvadoc.uva.es/handle/10324/63680
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 17-jul-2024