RT info:eu-repo/semantics/doctoralThesis
T1 Las alteraciones metabólicas y funcionales asociadas a la COVID-19
A1 Aparisi Sanz, Álvaro
A2 Universidad de Valladolid. Escuela de Doctorado
K1 COVID-19
K1 LDLc
K1 Long COVID
K1 Síndrome post-COVID
K1 Oxidative stress
K1 Estrés oxidativo
K1 32 Ciencias Médicas
AB The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been classified as a pandemic by the World Health Organization. Based on the characteristics of COVID-19 during the acute phase of the disease, it can be considered as the paradigm of viral sepsis. In daily clinical practice, much attention has been focused on identifying prognostic factors during the acute phase of the disease, with findings similar to those previously described in sepsis. However, these patients may also present metabolic and functional alterations, the exact pathophysiological mechanism of which is currently poorly understood. Research on COVID-19 and its chronicity will allow us to deepen our understanding of these alterations.The main objective is to describe the metabolic alterations and functional sequelae during the follow-up of patients with a previous history of SARS-CoV-2 infection or COVID-19. Secondary objectives include characterizing the behavior of the lipid profile in each phase of the disease, identifying existing prognostic associations, and comparing the functional parameters evaluated in patients with persistent symptoms.Our analysis showed that COVID-19 is associated with a transient decrease in the lipid profile (total cholesterol, LDL-c, and HDL-), likely secondary to increased oxidative stress and inflammation. LDL-c, along with inflammatory markers (C-reactive protein and IL-6), were independent biomarkers associated with all-cause mortality during the acute phase of COVID-19. Furthermore, long-term follow-up revealed an atherogenic profile among COVID-19 survivors with more intense oxidative responses at admission. We also observed that patients with persistent symptoms during follow-up had worse quality of life and a depressed functional class. Findings from the cardiopulmonary exercise testing suggest the presence of ventilatory inefficiency or hyperventilation syndrome.
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/63686
UL https://uvadoc.uva.es/handle/10324/63686
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 12-sep-2024