RT info:eu-repo/semantics/article
T1 Deficits of entropy modulation of the EEG: A biomarker for altered function in schizophrenia and bipolar disorder?
A1 Molina, Vicente
A1 Lubeiro, Alba
A1 de Luis Garcia, Rodrigo
A1 Gomez-Pilar, Javier
A1 Martín-Santiago, Oscar
A1 Iglesias-Tejedor, María
A1 Holgado-Madera, Pedro
A1 Segarra-Echeverría, Rafael
A1 Recio-Barbero, María
A1 Núñez, Pablo
A1 Haidar, Mahmoud Karim
A1 Fernández-Sevillano, Jessica
A1 Sanz-Fuentenebro, Javier
AB AbstractBackground: The synchronized activity of distributed neural assemblies — reflected in the electroencephalogram (EEG) — underpins mental function. In schizophrenia, modulation deficits of EEG spectral content during a P300 task have been replicated. The effects of treatment, chronicity and specificity in these deficits and their possible relationship with anatomic connectivity remain to be explored.Methods: We assessed spectral entropy modulation of the EEG during a P300 task in 79 patients with schizophrenia (of those, 31 werein their first episode), 29 patients with bipolar disorder and 48 healthy controls. Spectral entropy values summarize EEG characteristics by quantifying the irregularity of spectral content. In a subsample, we calculated the network architecture of structural connectivity using diffusion tensor imaging and graph-theory parameters.Results: We found significant spectral entropy modulation deficits with task performance in patients with chronic or first-episode schizophrenia and in patients with bipolar disorder, without significant pre-stimulus spectral entropy differences. The deficits were unrelated to treatment doses, and spectral entropy modulation did not differ between patients taking or not taking antipsychotics, lithium, benzodiazepines or antidepressants. Structural connectivity values were unrelated to spectral entropy modulation. In patients with schizophrenia, spectral entropy modulation was inversely related to negative symptoms and directly related to verbal memory.Limitations: All patients were taking medication. Patients with bipolar disorder were euthymic and chronic. The cross-sectional nature of this study prevented a more thorough analysis of state versus trait criteria for spectral entropy changes.Conclusion: Spectral entropy modulation with task performance is decreased in patients with schizophrenia and bipolar disorder. This deficit was not an effect of psychopharmacological treatment or structural connectivity and might reflect a deficit in the synchronization of the neural assemblies that underlie cognitive activity.
SN 1180-4882
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/63823
UL https://uvadoc.uva.es/handle/10324/63823
LA eng
NO J Psychiatry Neurosci. 2020 Sep 1;45(5):322-333
DS UVaDOC
RD 12-sep-2024