RT info:eu-repo/semantics/article
T1 Functional network properties in schizophrenia and bipolar disorder assessed with high-density electroencephalography
A1 Díez Revuelta, Álvaro
A1 Gómez Pilar, Javier
A1 Poza Crespo, Jesús
A1 Beño Ruiz De La Sierra, Rosa María
A1 Fernández Linsenbarth, Ines
A1 Recio Barbero, María
A1 Núñez Novo, Pablo
A1 Holgado Madera, Pedro
A1 Molina Rodríguez, Vicente
AB Background: The study of the cortical functional network properties in schizophrenia (SZ) may benefit from theuse of graph theory parameters applied to high-density electroencephalography (EEG). Connectivity Strength(CS) assesses global synchrony of the network, and Shannon Graph Complexity (SGC) summarizes the networkdistribution of link weights and allows distinguishing between primary and secondary pathways. Their joint usemay help in understanding the underpinnings of the functional network hyperactivation and task-relatedhypomodulation previously described in psychoses.Methods: We used 64-sensor EEG recordings during a P300 oddball task in 128 SZ patients (96 chronic, CR, and32 first episodes, FE), as well as 46 bipolar disorder (BD) patients, and 92 healthy controls (HC). Pre-stimulus andmodulation (task-response minus pre-stimulus windows values) of CS and SGC were assessed in the theta band(4–8 Hz) and the broadband (4–70 Hz).Results: Compared to HC, SZ patients (CR and FE) showed significantly higher pre-stimulus CS values in thebroadband, and both SZ and BD patients showed lower theta-band CS modulation. SGC modulation values, boththeta-band and broadband, were also abnormally reduced in CR patients. Statistically significant relationshipswere found in the theta band between SGC modulation and both CS pre-stimulus and modulation values inpatients. CS altered measures in patients were additionally related to their cognitive outcome and negativesymptoms. A primary role of antipsychotics in these results was ruled out.Conclusions: Our results linking SGC and CS alterations in psychotic patients supported a hyperactive andhypomodulatory network mainly involving connections in secondary pathways.
SN 0278-5846
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/63829
UL https://uvadoc.uva.es/handle/10324/63829
LA spa
NO Progress in Neuropsychopharmacology & Biological Psychiatry 129 (2024) 110902
DS UVaDOC
RD 05-feb-2025