RT info:eu-repo/semantics/article
T1 Structural connectivity in schizophrenia and bipolar disorder: Effects of chronicity and antipsychotic treatment
A1 Cea Cañas, Béquer Benjamín
A1 Luis García, Rodrigo de
A1 Lubeiro Juarez, Alba
A1 Gómez Pilar, Javier
A1 Sotelo, Eva
A1 del Valle, Pilar
A1 Gómez García, Marta
A1 Alonso Sánchez, Adrián
A1 Molina Rodríguez, Vicente
AB Previous studies based on graph theory parameters applied to diffusion tensor imaging support an alteration of the global properties of structural connectivity network in schizophrenia. However, the specificity of this alteration and its possible relation with chronicity and treatment have received small attention. We have assessed small-world (SW) and connectivity strength indexes of the structural network built using fractional anisotropy values of the white matter tracts connecting 84 cortical and subcortical regions in 25 chronic and 18 first episode (FE) schizophrenia and 24 bipolar patients and 28 healthy controls. Chronic schizophrenia and bipolar patients showed significantly smaller SW and connectivity strength indexes in comparison with controls and FE patients. SW reduction was driven by increased averaged path-length (PL) values. Illness duration but not treatment doses were negatively associated with connectivity strength, SW and PL in patients. Bipolar patients exposed to antipsychotics did not differ in SW or connectivity strength from bipolar patients without such an exposure. Executive functions and social cognition were related to SW index in the schizophrenia group. Our results support a role for chronicity but not treatment in structural network alterations in major psychoses, which may not differ between schizophrenia and bipolar disorder, and may hamper cognition.
SN 0278-5846
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/63840
UL https://uvadoc.uva.es/handle/10324/63840
LA spa
NO Prog Neuropsychopharmacol Biol Psychiatry . 2019 Jun 8:92:369-377
DS UVaDOC
RD 04-mar-2025