RT info:eu-repo/semantics/article
T1 Synthesis and iNOS/nNOS inhibitory activities of new benzoylpyrazoline derivatives
A1 Carrión, M.Dora
A1 Camacho, M.Encarnación
A1 León, Josefa
A1 Escames, Germaine
A1 Tapias Molina, Víctor
A1 Acuña Castroviejo, Darío
A1 Gallo, Miguel A
A1 Espinosa, Antonio
AB A series of new Δ2-pyrazoline derivatives has been synthesized by means of a 1,3-dipolar-cycloaddition reaction. Ethyl 3-(5-methoxy-2-nitrobenzoyl)-Δ2-pyrazoline-5-carboxylate (5a) has been designed for the formation of the benzoylpyrazoline system present in these derivatives. Two synthetic routes have been utilized changing the starting products in the cycloaddition reaction. In both routes, the majority product obtained was only a Δ2-pyrazoline. The intermediate ethyl 1-acyl-3-(2-nitrobenzoyl-5-substituted)-Δ2-pyrazoline-5-carboxylate derivatives have been transformed into the final compounds by means of several chemical treatments. The compounds have been biologically evaluated as inhibitors of nitric oxide synthase (NOS), showing better affinity towards the inducible NOS isoform than versus neuronal NOS.
SN 0040-4020
YR 2004
FD 2004
LK https://uvadoc.uva.es/handle/10324/63866
UL https://uvadoc.uva.es/handle/10324/63866
LA eng
NO Tetrahedron, Abril 2004, vol. 60, n. 18, p. 4051-4069
NO Producción Científica
DS UVaDOC
RD 07-ene-2025