RT info:eu-repo/semantics/article
T1 Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors
A1 López Cara, Luisa C.
A1 Camacho, M. Encarnación
A1 Carrión, M. Dora
A1 Tapias Molina, Victor
A1 Gallo, Miguel A.
A1 Escames, Germaine
A1 Acuña Castroviejo, Darío
A1 Espinosa, Antonio
A1 Entrena, Antonio
AB We have previously described a series of 3-phenyl-4,5-dihydro-1H-pyrazole derivatives as moderately potent nNOS inhibitors. As a follow up of these studies, several new 5-phenyl-1H-pyrrole-2-carboxamide derivatives have been synthesized, and their biological evaluation as in vitro inhibitors of both neural and inducible Nitric Oxide Synthase (nNOS and iNOS) is described. Some of these compounds show good iNOS/nNOS selectivity and the more potent compounds 5-(2-aminophenyl)-1H-pyrrole-2-carboxilic acid methylamide (QFF205) and cyclopentylamide (QFF212) have been tested as regulators of the in vivo nNOS and iNOS activity. Both compounds prevented the increment of the inducible NOS activity in both cytosol (iNOS) and mitochondria (i-mtNOS) observed in the MPTP model of Parkinson's disease.
SN 0223-5234
YR 2009
FD 2009
LK https://uvadoc.uva.es/handle/10324/63872
UL https://uvadoc.uva.es/handle/10324/63872
LA eng
NO European Journal of Medicinal Chemistry, Junio 2009, vol. 44, n. 6, p. 2655-2566
NO Producción Científica
DS UVaDOC
RD 04-abr-2025