RT info:eu-repo/semantics/article
T1 Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism
A1 Allen, Erika N.
A1 Potdar, Sneha
A1 Tapias, Victor
A1 Parmar, Mayur
A1 Mizuno, Cassia S.
A1 Rimando, Agnes
A1 Cavanaugh, Jane E.
AB Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.
SN 0955-2863
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/63890
UL https://uvadoc.uva.es/handle/10324/63890
LA eng
NO The Journal of Nutritional Biochemistry, Abril 2018, vol. 54. p. 77-86
NO Producción Científica
DS UVaDOC
RD 14-oct-2024