RT info:eu-repo/semantics/article
T1 Blueberry juice augments exercise-induced neuroprotection in a Parkinson’s disease model through modulation of GDNF levels
A1 Castro, Sandra L.
A1 Tapias Molina, Víctor
A1 Gathagan, Ronald
A1 Emes, Alexandra
A1 Brandon, Taylor E.
A1 Smith, Amanda D.
AB Exercise and consumption of plant-based foods rich in polyphenols are attractive therapeutic approaches for the prevention and treatment of Parkinson's disease (PD). Few studies, however, have examined the neuroprotective efficacy of combining these treatment modalities against PD. Therefore we investigated whether combining voluntary running and consumption of blueberry juice (BBJ) was more efficacious against 6-hydroxydopamine (6-OHDA) toxicity than either treatment alone. Four weeks of running before and after intrastriatal 6-OHDA reduced amphetamine-induced rotational behavior and loss of substantia nigra dopamine (DA) neurons. BBJ consumption alone had no ameliorative effects, but when combined with exercise, behavioral deficits and nigrostriatal DA neurodegeneration were reduced to a greater extent than exercise alone. The neuroprotection observed with exercise alone was associated with an increase in striatal glial cell-lined derived neurotrophic factor (GDNF), whereas combining exercise and BBJ was associated with an increase in nigral GDNF. These results suggest that polyphenols may potentiate the protective effects of exercise and that differential regulation of GDNF expression underlies protection observed with exercise alone versus combined treatment with consumption of BBJ.
SN 2667-2421
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/63897
UL https://uvadoc.uva.es/handle/10324/63897
LA eng
NO IBRO Neuroscience Reports, Marzo 2022, vol. 12. p. 217-227
NO Producción Científica
DS UVaDOC
RD 26-dic-2024