RT info:eu-repo/semantics/article
T1 Environmental enrichment improves traumatic brain injury-induced behavioral phenotype and associated neurodegenerative process
A1 Tapias Molina, Víctor
A1 Moschonas, Eleni H.
A1 Bondi, Corina O.
A1 Vozzella, Vincent J.
A1 Cooper, Iya N.
A1 Cheng, Jeffrey P.
A1 Lajud, Naima
A1 Kline, Anthony E.
AB Traumatic brain injury (TBI) causes persistent cognitive impairment and neurodegeneration. Environmental enrichment (EE) refers to a housing condition that promotes sensory and social stimulation and improves cognition and motor performance but the underlying mechanisms responsible for such beneficial effects are not well defined. In this study, anesthetized adult rats received either a moderate-to-severe controlled cortical impact (CCI) or sham surgery and then were housed in either EE or standard conditions. The results showed a significant increase in protein nitration and oxidation of lipids, impaired cognition and motor performance, and augmented N-methyl-d-aspartate receptor subtype-1 (NMDAR1) levels. However, EE initiated 24 h after CCI resulted in reduced oxidative insult and microglial activation and significant improvement in beam-balance/walk performance and both spatial learning and memory. We hypothesize that following TBI there is an upstream activation of NMDAR that promotes oxidative insult and an inflammatory response, thereby resulting in impaired behavioral functioning but EE may exert a neuroprotective effect via sustained downregulation of NMDAR1.
SN 0014-4886
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/63899
UL https://uvadoc.uva.es/handle/10324/63899
LA eng
NO Experimental Neurology, Noviembre 2022, vol. 357. p. 114204
NO Producción Científica
DS UVaDOC
RD 26-dic-2024