RT info:eu-repo/semantics/article
T1 unexpected toxicity of green tea polyphenols in combination with the sambucus ril ebulin
A1 Rojo, M. Ángeles
A1 Garrosa, Manuel
A1 Jiménez, Pilar
A1 Girbés, Tomás
A1 Garcia-Recio, Verónica
A1 Cordoba-Diaz, Manuel
A1 Cordoba-Diaz, Damián
K1 green tea polyphenols
K1 Sambucus ebulus
K1 ebulin f
K1 RIP
K1 ribosome-inactivating protein
K1 ricin
AB The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
PB MDPI
SN 2072-6651
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/64333
UL https://uvadoc.uva.es/handle/10324/64333
LA eng
NO Toxins 2020,12,542-553
NO Producción Científica
DS UVaDOC
RD 18-nov-2024