RT info:eu-repo/semantics/article
T1 unexpected toxicity of green tea polyphenols in combination with the sambucus ril ebulin
A1 Rojo, M. Ángeles
A1 Garrosa García, Manuel
A1 Jiménez López, María del Pilar
A1 Girbés, Tomás
A1 Garcia-Recio, Verónica
A1 Cordoba-Diaz, Manuel
A1 Cordoba-Diaz, Damián
K1 green tea polyphenols
K1 Sambucus ebulus
K1 ebulin f
K1 RIP
K1 ribosome-inactivating protein
K1 ricin
AB The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
PB MDPI
SN 2072-6651
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/64333
UL https://uvadoc.uva.es/handle/10324/64333
LA eng
NO Toxins 2020,12,542-553
NO Producción Científica
DS UVaDOC
RD 27-dic-2024