RT info:eu-repo/semantics/article
T1 Development and validation of UHPLC–MS/MS methods for determination of neonicotinoid insecticides in royal jelly-based products
A1 Valverde Bastardo, Silvia
A1 Ares Sacristán, Ana María
A1 Arribas, Mario
A1 Bernal Yagüe, José Luis
A1 Nozal Nalda, María Jesús del
A1 Bernal del Nozal, José
K1 DLLME; Food analysis; Food composition; Food safety; Insecticides; Neonicotinoids; Royal jelly; SPE; UHPLC–MS/MS
AB In this study, new methods have been proposed to determine seven neonicotinoid insecticides (dinotefuran,nitenpyram, thiamethoxam, clothianidin, imidacloprid, acetamiprid and thiacloprid) in royal jelly-based products, by means of ultra-high-performance liquid chromatography coupled to a quadrupole-time-of-flight mass detector. Efficient sample treatments (with average analyte recoveries between 83% and 109%) involving solid phase extraction (polymeric sorbent, Strata® X) and a dispersive liquid–liquid microextraction, were proposed to determine these neonicotinoids in liquid dietary supplements containing freeze-dried royal jelly and fresh royal jelly, respectively. Chromatographic analysis (8 min) was performed on a core-shell technology-based column (Kinetex® EVO C18). Both methods were fully validated and the data demonstrated that they are consistent, reliable and have a wide linear range of applicability. Low limits of quantification, ranging from 2.5 to 9.5 μg/kg, were obtained in all cases, and it was necessary to employ matrix-matched standards for correct quantification of three of the compounds in each of the royal jelly-based products. Finally, the proposed methods were applied to neonicotinoid analysis of royal jelly-based products from different Spanish regions.
PB Elsevier
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/64398
UL https://uvadoc.uva.es/handle/10324/64398
LA eng
NO Journal of Food Composition and Analysis, Mayo 2018, vol. 70. p. 105-113.
NO Producción Científica
DS UVaDOC
RD 26-dic-2024