RT info:eu-repo/semantics/article
T1 Lipid peroxidation as a hallmark of severity in COVID-19 patients
A1 Martín Fernández, Marta
A1 Aller de la Fuente, Rocío
A1 Heredia Rodríguez, María
A1 Gómez-Sánchez, Esther
A1 Martínez de Paz, Pedro José
A1 Gonzalo Benito, Hugo
A1 Sánchez de Prada, Laura
A1 Gorgojo Galindo, Óscar
A1 Carnicero Frutos, Irene
A1 Tamayo Gómez, Eduardo
A1 Tamayo Velasco, Álvaro
AB Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in responseto infections. A defective redox balance has been related to viral pathogenesis developing a massive induction ofcell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profileevaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order tocharacterize its role in diagnosis and severity of this disease.Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/deathrisk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzedby using Kaplan-Meier curves and tested with the log-rank test.Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyland Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidantcapacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP(LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57;95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patientsshowing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001).Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supportingits important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higherrisk of intubation or death at 28 days in COVID-19 patients.
PB elsevier
SN 2213-2317
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/64526
UL https://uvadoc.uva.es/handle/10324/64526
LA spa
NO Redox Biol. 2021 Nov 6;48:102181
DS UVaDOC
RD 06-feb-2025