RT info:eu-repo/semantics/article
T1 Common polymorphism in the cannabinoid receptor gene type 2 (CB2R) rs3123554 are associated with metabolic changes after two different hypocaloric diets with different dietary fatty profiles
A1 Aller de la Fuente, Rocío
A1 Primo, D.
A1 Izaola, O.
A1 de Luis, D.A.
AB Background: The role of CB2R gene variants on weight loss after a dietary intervention has been investigated in few studies.Objective: We evaluate the effect of this genetic variant (rs3123554) of CB2R gene on cardiovascular riskfactors and weight loss secondary to high monounsaturated fat vs a high polyunsaturated fat hypocaloricdiets.Design: A Caucasian population of 362 obese patients was enrolled. Patients were randomly allocatedduring 3 months to one of two diets (Diet P high polyunsaturated (PUFAs) fat hypocaloric diet vs, Diet Mhigh monounsaturated (MUFAs) fat hypocaloric diet).Results: In both genotype groups (GG vs GAþAA), body weight, body mass index (BMI), fat mass, waistcircumference and systolic blood pressure decreased after diet P and M. Body weight, BMI, fat mass andwaist circumference were higher in A allele carriers than non A allele carriers. The improvement of theseparameters was higher in non A allele carriers than A allele carriers. In non A allele carriers with bothdiets, the decrease of total cholesterol, LDL-cholesterol, insulin and HOMA-IR was higher than A allelecarriers after both diets. After diet P, triglyceride levels decrease in non A allele carriers.Conclusion: Our data suggest that carriers of the minor allele of rs3123554 variant of CB2R gene lose lessbody weight during to different hypocaloric diets with different fatty acid. Moreover, non A-allele carriers showed a better response of LDL-cholesterol, HOMA-IR and insulin levels than A-carriers with bothhypocaloric diets
SN 0261-5614
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/64528
UL https://uvadoc.uva.es/handle/10324/64528
LA spa
NO Clin Nutr. 2019 Dec;38(6):2632-2638
DS UVaDOC
RD 04-dic-2024