RT info:eu-repo/semantics/article
T1 The effect of single-nucleotide polymorphisms at the ADIPOQ gene locus rs1501299 on metabolic parameters after 9 mo of a high-protein/low-carbohydrate versus a standard hypocaloric diet
A1 Aller de la Fuente, Rocío
A1 Izaola, Olatz
A1 Primo, David
A1 de Luis, Daniel Antonio
AB Objective: Some adiponectin gene (ADIPOQ) single-nucleotide polymorphisms (SNPs) have been related tobasal and adiponectin levels and metabolic parameters. The aim of this study was to evaluate the effect ofthe genetic variant rs1501299 ADIPOQ gene on biochemical changes after weight loss secondary to a highprotein and low-carbohydrate diet versus a standard severe hypocaloric diet over 9 mo as the primaryendpoint.Methods: A white population of 270 obese patients was enrolled in a randomized clinical trial with two hypocaloric diets (high-protein and low carbohydrate diet [HP] versus standard diet [S]) over 9 mo of intervention. The statistical analysis was performed for the combined GT and TT as a group (T-allele carriers) and GGas second group (non T-allele carriers). Before and after 12 wk on each hypocaloric diet, an anthropometricevaluation, an assessment of nutritional intake, and a biochemical analysis were realized.Results: With both dietary interventions, body weight, body mass index (BMI), fat mass, waist circumference,systolic blood pressure, and leptin levels decreased. In non T-allele carriers after both diets, the decrease intotal cholesterol levels  12.3 § 2.2 mg/dL (T-allele carriers  6.9 § 2.1 mg/dL; P = 0.01 diet HP) and 12.2 §3.1 mg/dL (T-allele carriers  4.7 § 1.2 mg/dL; P = 0.02 after diet S), low-density lipoprotein cholesterol  13.2§ 2.7 mg/dL (T-allele carriers  6.1 § 2.1 mg/dL; P = 0.02 after diet HP) and  9.3 § 1.8 mg/dL (T-allele carriers 4.8 § 2.9 mg/dL; P = 0.01 after diet S), triacylglycerol levels  12.7 § 6.1 mg/dL (T-allele carriers  6 § 2.9mg/dL; P = 0.01 after diet HP) and  16.3 § 7.2 mg/dL (T-allele carriers  5.3 § 1.4 mg/dL; P = 0.03 after dietS), insulin levels  5 § 1.1 mUI/L (in T-allele  1.7 § 0.9 mUI/L; P = 0.02 after diet HP) and  3.2 1.1 mUI/L(T-allele carriers  0.7 § 0.7 mUI/L; P = 0.02 after diet S), and homeostatic model assessment of insulin resistance levels  0.4 § 0.2 units (T-allele group  0.1 § 0.1; P = 0.04 after diet HP) and  0.7 § 0.1 units (T-allelecarriers  0.1 § 0.5 mg/dL; P = 0.01 after diet S) was higher than T-allele carriers. Only no T-allele carriersshowed an increase in adiponectin levels after both diets.Conclusion: After two different hypocaloric diets during 9 mo of intervention, the GG genotype of an ADIPOQgene variant (rs1501299) is related to better improvement in adiponectin levels, insulin resistance, and lipidprofile than T-allele carriers
SN 0899-9007
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/64573
UL https://uvadoc.uva.es/handle/10324/64573
LA spa
NO Nutrition. 2019 Sep;65:44-49
DS UVaDOC
RD 21-may-2024