RT info:eu-repo/semantics/article T1 Dietary Recommendations for the Management of Non-alcoholic Fatty Liver Disease (NAFLD): A Nutritional Geometry Perspective A1 Romero-Gómez, Manuel A1 Aller de la Fuente, Rocío A1 Martín-Bermudo, Franz AB Diet could be both culprit and solution of NAFLD. Dietary modifications have beenassociated with histological features improvement in NAFLD. The Western diet wasrelated to a greater risk of disease progression while theMediterranean diet (MD) couldpromote regression of histological lesions. Modifications in the nutrient compositionseems to have lesser impact on NAFLD than dietary modifications. An intrinsicinteraction between nutrients in the diet support a specific effect not seen whenadded separately. Dietary modifications should focus on promoting weight loss butalso look for patterns that are able to promote histological improvement. Althoughseveral micronutrients’ deficit has been related to NAFLD progression, prescribingthese micronutrients’ supplementation did not reach a positive impact. However, anenriching diet with specific nutrients could be useful, like olive oil supplemented inMD.Geometry of nutrition defines a framework to better understand the interactionbetween nutrients, foods, and dietetic pattern in the model of diseases and how wecould approach taking into consideration the interaction between meals and diseasefeatures. After analyzing baseline diet and histological lesions, we could calculate thedistance to optimal diet and to promote changes in lifestyle to reach all these goals. Astandard MD menu would be recommended. SN 0272-8087 YR 2022 FD 2022 LK https://uvadoc.uva.es/handle/10324/64576 UL https://uvadoc.uva.es/handle/10324/64576 LA spa NO Semin Liver Dis. 2022 Nov;42(4):434-445 DS UVaDOC RD 24-nov-2024