RT info:eu-repo/semantics/article
T1 Modifications of serum levels of omentin-1 and other cardiovascular risk factors following weight loss secondary to a Mediterranean hypocaloric diet
A1 Antonio de Luis, Daniel
A1 Izaola, Olatz
A1 Primo, David
A1 Aller de la Fuente, Rocío
AB Background & aims: Omentin-1 might play a role on insulin resistance, dyslipidemia and obesity. The aimof this investigation was to evaluate the influence of weight loss on omentin-1 concentrations after ahypocaloric diet with Mediterranean pattern.Methods: A Caucasian sample of 67 obese patients was analyzed before and after 3 months on ahypocaloric diet. Anthropometric parameters, blood pressure, fasting blood glucose, C-reactive protein(CRP), fasting insulin, insulin resistance (HOMA-IR), lipid concentrations and omentin-1 were measured.Results: Sixty-seven obese subjects were enrolled in the study. The mean age was 48.3 ± 8.0 years(range: 25e66) and the mean BMI 34.5 ± 4.8 kg/m2 (range: 30.2e40.8). Gender distribution was 50females (74.6%) and 17 males (25.4%). After dietary intervention and in males and females; body massindex, weight, fat mass, waist circumference, blood pressure, glucose, LDL cholesterol, insulin andHOMA-IR decreased. Omentin-1 levels increase after dietary intervention (males vs females) (delta basalvs 3 months: 10.0 ± 3.8 ng/dl: p ¼ 0.01 vs 9.9 ± 4.1 ng/dl; p ¼ 0.03). In the multiple regression analysisadjusted for age and sex; BMI and insulin remained independently associated with baseline and posttreatment levels of omentin-1.Conclusions: Our investigation showed a significant increase in omentin-1 levels after weight loss secondary to a hypocaloric diet with a Mediterranean pattern.
SN 0261-5614
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/64580
UL https://uvadoc.uva.es/handle/10324/64580
LA eng
NO Clin Nutr. 2018 Dec;37(6 Pt A):2280-2283
DS UVaDOC
RD 14-jul-2024