RT info:eu-repo/semantics/article
T1 Role of rs1501299 variant in the adiponectin gene on total adiponectin levels, insulin resistance and weight loss after a Mediterranean hypocaloric diet
A1 de Luis, Daniel Antonio
A1 Izaola, Olatz
A1 Primo, David
A1 Gómez Hoyos, Emilia
A1 Ortola, Ana
A1 López Gómez, Juan José
A1 Aller de la Fuente, Rocío
AB Background/Aim: Several adiponectin gene (ADIPOQ) single nucleotide polymorphisms(SNPS) have been related with adiponectin levels and risk for obesity. Our aim was to analyze the effects of rs1501299 ADIPOQ gene polymorphism on total adiponectin levels, insulinresistance and weight loss after a Mediterranean hypocaloric diet in obese subjects.Methods: A Caucasian population of 82 obese patients was analyzed, before and after3 months on a Mediterranean hypocaloric diet. Before and after 3 months on a hypocaloricdiet, an anthropometric evaluation, an assessment of nutritional intake and a biochemicalanalysis were performed.Results: After dietary treatment and in wild type group, weight, BMI, fat mass, leptin levels,systolic blood pressure and waist circumference decreases were similar to the mutant typegroup. In wild type group, the decrease in total cholesterol was  28.1 ± 15.3 mg/dl (mutantgroup:  12.6 ± 16.7 mg/dl:p = 0.009), LDL- cholesterol was  31.8 ± 20.5 mg/dl ( 12.2± 11.5 mg/dl:p = 0.006), fasting glucose plasma  4.8 ± 2.5 mg/dL ( 0.5 ± 0.1 mg/dL:p = 0.02),insulin  3.6 ± 1.5 mUI/L (+0.6 ± 1.1 mUI/L:p = 0.02) and HOMA-IR  1.2 ± 0.9 ( 0.1 ± 1.1:p = 0.03).Conclusion: The present study suggests that T allele of ADIPO (rs1501299) could be a predictor of a lack of response of HOMA-IR, insulin, fasting glucose and LDL cholesterol secondaryto a Mediterranean hypocaloric diet in obese subjects.
SN 0168-8227
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/64590
UL https://uvadoc.uva.es/handle/10324/64590
LA eng
NO Diabetes Res Clin Pract. 2019 Feb;148:262-267
DS UVaDOC
RD 22-dic-2024