RT info:eu-repo/semantics/article
T1 Current gaps in sepsis immunology: new opportunities for translational research
A1 Rubio, Ignacio
A1 Osuchowski, Marcin F
A1 Shankar-Hari, Manu
A1 Skirecki, Tomasz
A1 Winkler, Martin Sebastian
A1 Lachmann, Gunnar
A1 La Rosée, Paul
A1 Monneret, Guillaume
A1 Venet, Fabienne
A1 Bauer, Michael
A1 Brunkhorst, Frank M
A1 Kox, Matthijs
A1 Cavaillon, Jean-Marc
A1 Uhle, Florian
A1 Weigand, Markus A
A1 Flohé, Stefanie B
A1 Wiersinga, W Joost
A1 Martín Fernández, Marta
A1 Almansa, Raquel
A1 Martin-Loeches, Ignacio
A1 Torres, Antoni
A1 Giamarellos-Bourboulis, Evangelos J
A1 Girardis, Massimo
A1 Cossarizza, Andrea
A1 Netea, Mihai G
A1 van der Poll, Tom
A1 Scherag, André
A1 Meisel, Christian
A1 Schefold, Joerg C
A1 Bermejo-Martín, Jesús F
AB Increasing evidence supports a central role of the immune system in sepsis, but the current view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how immunological alterations predispose to sepsis, key aspects of the immunopathological events during sepsis, and the long-term consequences of sepsis on patient's immunity. We discuss major unmet topics in those three categories, including the role of key immune cells, the cause of lymphopenia, organ-specific immunology, the dynamics of sepsis-associated immunological alterations, the role of the microbiome, the standardisation of immunological tests, the development of better animal models, and the opportunities offered by immunotherapy. Addressing these gaps should help us to better understand sepsis physiopathology, offering translational opportunities to improve its prevention, diagnosis, and care.
SN 1473-3099
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/64660
UL https://uvadoc.uva.es/handle/10324/64660
LA eng
NO Lancet Infect Dis. 2019 Dec;19(12):e422-e436
NO Producción Científica
DS UVaDOC
RD 24-nov-2024