RT info:eu-repo/semantics/article
T1 MR‐ proADM to detect specific types of organ failure in infection
A1 Andrés, Cristina
A1 Andaluz Ojeda, David
A1 Cicuendez, Ramón
A1 Nogales, Leonor
A1 Martín, Silvia
A1 Martín Fernández, Marta
A1 Almansa, Raquel
A1 Calvo, Dolores
A1 Esteban‐Velasco, Maria Carmen
A1 Vaquero‐Roncero, Luis Mario
A1 Ríos‐Llorente, Alberto
A1 Sanchez‐Barrado, Elisa
A1 Muñoz‐Bellvís, Luis
A1 Aldecoa, César
A1 Bermejo‐Martin, Jesus F.
AB Background: Following the SEPSIS-3 consensus, detection of organ failure as assessed by the SOFA (Sequential Organ Failure Assessment) score, is mandatory to detect sepsis. Calculating SOFA outside of the Intensive Care Unit (ICU) is challenging. The alternative in this scenario, the quick SOFA, is very specific but less sensible. Biomarkers could help to detect the presence of organ failure secondary to infection either in ICU and non-ICU settings.Materials and methods: We evaluated the ability of four biomarkers (C-Reactive protein (CRP), lactate, mid-regional proadrenomedullin (MR-proADM) and procalcitonin (PCT)) to detect each kind of organ failure considered in the SOFA in 213 patients with infection, sepsis or septic shock, by using multivariate regression analysis and calculation of the area under the receiver operating curve (AUROC).Results: In the multivariate analysis, MR-proADM was an independent predictor of five different failures (respiratory, coagulation, cardiovascular, neurological and renal). In turn, lactate predicted three (coagulation, cardiovascular and neurological) and PCT two (cardiovascular and renal). CRP did not predict any of the individual components of SOFA. The highest AUROCs were those of MR-proADM and PCT to detect cardiovascular (AUROC, CI95%): MR-proADM (0.82 [0.76-0.88]), PCT (0.81 [0.75-0.87] (P < .05) and renal failure: MR-proADM (0.87 [0.82-0.92]), PCT (0.81 [0.75-0.86]), (P < .05). None of the biomarkers tested was able to detect hepatic failure.Conclusions: In patients with infection, MR-proADM was the biomarker detecting the largest number of SOFA score components, with the exception of hepatic failure.
SN 0014-2972
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/64661
UL https://uvadoc.uva.es/handle/10324/64661
LA eng
NO Eur J Clin Invest. 2020 Jun;50(6):e13246
NO Producción Científica
DS UVaDOC
RD 25-nov-2024