RT info:eu-repo/semantics/article
T1 Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
A1 Molina, Vicente
A1 Bachiller, Alejandro
A1 de Luis, Rodrigo
A1 Lubeiro, Alba
A1 Poza, Jesús
A1 Hornero, Roberto
A1 Alonso, Joan Francesc
A1 Mañanas, Miguel Angel
A1 Marqués, Patricia
A1 Romero, Sergio
K1 Schizophrenia · LORETA · EEG · Diffusion tensor · Anterior cingulate
AB Background The study of cerebral underpinnings of schizophrenia may benefit from the high temporal resolution of electromagnetictechniques, but its spatial resolution is low. However, source imaging approaches such as low-resolution brainelectromagnetic tomography (LORETA) allow for an acceptable compromise between spatial and temporal resolutions.Methods We combined LORETA with 32 channels and 3-Tesla diffusion magnetic resonance (Dmr) to study cerebraldysfunction in 38 schizophrenia patients (17 first episodes, FE), compared to 53 healthy controls. The EEG was acquiredwith subjects performing an odd-ball task. Analyses included an adaptive window of interest to take into account the interindividualvariability of P300 latency. We compared source activation patters to distractor (P3a) and target (P3b) toneswithin- and between-groups.Results Patients showed a reduced activation in anterior cingulate and lateral and medial prefrontal cortices, as well asinferior/orbital frontal regions. This was also found in the FE patients alone. The activation was directly related to IQ inthe patients and controls and to working memory performance in controls. Symptoms were unrelated to source activation.Fractional anisotropy in the tracts connecting lateral prefrontal and anterior cingulate regions predicted source activation inthese regions in the patients.Conclusions These results replicate the source activation deficit found in a previous study with smaller sample size anda lower number of sensors and suggest an association between structural connectivity deficits and functional alterations.
PB Springer-Verlag
SN 0940-1334
YR 2019
FD 2019-06
LK https://uvadoc.uva.es/handle/10324/64695
UL https://uvadoc.uva.es/handle/10324/64695
LA eng
NO Eur Arch Psychiatry Clin Neurosci. 2019 Jun;269(4):419-428
NO Producción Científica
DS UVaDOC
RD 25-nov-2024