RT info:eu-repo/semantics/article
T1 Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis
A1 Pérez Castrillon, José Luis
K1 Endocrinologia y Metabolismo
K1 vitamin D receptor; VDR; vitamin D; polymorphisms; TaqI; FokI; vitamin D supplementation
AB The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptionalregulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmentalfactors and it is hypothesised that the response to vitamin D supplementation could be modulatedby genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal(rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic reviewand meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI,TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship betweenthe response to vitamin D supplementation and the genotypic distribution of these polymorphisms.We included eight studies that enrolled 1038 subjects. The results showed no significant associationwith the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt)of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a betterresponse to vitamin D supplementation (p = 0.02 and p < 0.001). In conclusion, the TaqI and FokIpolymorphisms could play a role in the modulation of the response to vitamin D supplementation, asthey are associated with a better response to supplementation.
PB MDPI
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/64706
UL https://uvadoc.uva.es/handle/10324/64706
LA eng
NO Nutrients 2022, 14, 360-369
NO Producción Científica
DS UVaDOC
RD 11-ene-2025