RT info:eu-repo/semantics/article
T1 Measuring Alterations of Spontaneous EEG Neural Coupling in Alzheimer's Disease and Mild Cognitive Impairment by Means of Cross-Entropy Metrics
A1 Ruiz Gómez, Saúl José
A1 Gómez Peña, Carlos
A1 Poza Crespo, Jesús
A1 Martínez Zarzuela, Mario
A1 Tola Arribas, Miguel Ángel
A1 Cano, Mónica
A1 Hornero Sánchez, Roberto
AB Alzheimer's Disease (AD) represents the most prevalent form of dementia and is considered a major health problem due to its high prevalence and its economic costs. An accurate characterization of the underlying neural dynamics in AD is crucial in order to adopt effective treatments. In this regard, mild cognitive impairment (MCI) is an important clinical entity, since it is a risk-state for developing dementia. In the present study, coupling patterns of 111 resting-state electroencephalography (EEG) recordings were analyzed. Specifically, we computed Cross-Approximate Entropy (Cross-ApEn) and Cross-Sample Entropy (Cross-SampEn) of 37 patients with dementia due to AD, 37 subjects with MCI, and 37 healthy control (HC) subjects. Our results showed that Cross-SampEn outperformed Cross-ApEn, revealing higher number of significant connections among the three groups (Kruskal-Wallis test, FDR-corrected p-values < 0.05). AD patients exhibited statistically significant lower similarity values at θ and β1 frequency bands compared to HC. MCI is also characterized by a global decrease of similarity in all bands, being only significant at β1. These differences shows that β band might play a significant role in the identification of early stages of AD. Our results suggest that Cross-SampEn could increase the insight into brain dynamics at different AD stages. Consequently, it may contribute to develop early AD biomarkers, potentially useful as diagnostic information.
PB Frontiers
YR 2018
FD 2018-10-30
LK https://uvadoc.uva.es/handle/10324/64732
UL https://uvadoc.uva.es/handle/10324/64732
LA eng
NO Ruiz-Gómez SJ, Gómez C, Poza J, Martínez-Zarzuela M, Tola-Arribas MA, Cano M and Hornero R (2018) Measuring Alterations of Spontaneous EEG Neural Coupling in Alzheimer's Disease and Mild Cognitive Impairment by Means of Cross-Entropy Metrics. Front. Neuroinform. 12:76. doi: 10.3389/fninf.2018.00076
NO Producción Científica
DS UVaDOC
RD 12-sep-2024