RT info:eu-repo/semantics/article
T1 Impact of an oral nutritional supplement enriched in leucine, EPA, DHA, and β-glucans on the increase of muscle mass in patients with cancer and malnutrition: The alisenoc trial
A1 Luis Román, Daniel Antonio de
AB Methods: A randomized, double-blind, parallel-group, controlled, multicenter clinical trial was conducted inpatients with cancer and malnutrition during outpatient treatment. Patients were randomized to receive either aspecific high-calorie, high-protein ONS enriched with leucine, EPA, DHA, and β-glucans or an isocaloric, isonitrogenousstandard ONS for eight weeks. Malnutrition was diagnosed using the SGA and body composition wasevaluated using bioimpedance.Results: 57 patients were recruited and 37 completed the intervention period. After the nutritional intervention,patients who received the enhanced-ONS showed a significant increase in muscle mass, which was not detectedwith the standard ONS [1.92 (4.31) kg vs ����� 0.68 (1.45) kg); p = 0.009)], and there was no significant reduction inthe percentage of patients with severe and moderate malnutrition.Conclusion: An enhanced ONS enriched in EPA, DHA, leucine, and β-glucans increases muscle mass and couldpromote nutritional and functional status recovery in patients with cancer and malnourishment
PB Elsevier
SN 1756-4646
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/64844
UL https://uvadoc.uva.es/handle/10324/64844
LA eng
NO Journal of Functional Foods 110 (2023) 105833
DS UVaDOC
RD 19-nov-2024