RT info:eu-repo/semantics/article
T1 Impact of an oral nutritional supplement enriched in leucine, EPA, DHA, and β-glucans on the increase of muscle mass in patients with cancer and malnutrition: The alisenoc trial
A1 Vidal Casariego, Alfonso
A1 García Luna, Pedro Pablo
A1 Villazón González, Francisco
A1 Martín Folgueras, Tomás
A1 Palma Milla, Samara
A1 López Gómez, Juan José
A1 González Navarro, Irene
A1 Calleja Fernández, Alicia
A1 Casañas Quintana, Tamara
A1 López Plaza, Bricia
A1 Luis Román, Daniel Antonio de
AB Methods: A randomized, double-blind, parallel-group, controlled, multicenter clinical trial was conducted inpatients with cancer and malnutrition during outpatient treatment. Patients were randomized to receive either aspecific high-calorie, high-protein ONS enriched with leucine, EPA, DHA, and β-glucans or an isocaloric, isonitrogenousstandard ONS for eight weeks. Malnutrition was diagnosed using the SGA and body composition wasevaluated using bioimpedance.Results: 57 patients were recruited and 37 completed the intervention period. After the nutritional intervention,patients who received the enhanced-ONS showed a significant increase in muscle mass, which was not detectedwith the standard ONS [1.92 (4.31) kg vs ����� 0.68 (1.45) kg); p = 0.009)], and there was no significant reduction inthe percentage of patients with severe and moderate malnutrition.Conclusion: An enhanced ONS enriched in EPA, DHA, leucine, and β-glucans increases muscle mass and couldpromote nutritional and functional status recovery in patients with cancer and malnourishment
PB Elsevier
SN 1756-4646
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/64844
UL https://uvadoc.uva.es/handle/10324/64844
LA eng
NO Journal of Functional Foods, 2023, vol. 110, 105833
NO Producción Científica
DS UVaDOC
RD 10-abr-2025