RT info:eu-repo/semantics/article
T1 Cross-linked hyaluronan films loaded with acetazolamide–cyclodextrin–triethanolamine complexes for glaucoma treatment
A1 Calles, Javier Adrián
A1 Mora, Maria Julia
A1 Onnainty, Renée
A1 Tartara, Luis Ignacio
A1 Granero, Gladys Ester
A1 Longhi, Marcela Raquel
A1 Diebold Luque, María Yolanda
A1 Vallés, Enrique Marcelo
A1 Palma, Santiago Daniel
K1 Oftalmología
K1 Glaucoma
K1 Glaucoma
K1 Acetazolamide
K1 Cyclodextrin inclusion complex
K1 Acetazolamida
K1 Complejo de inclusión de ciclodextrina
K1 3201.09 Oftalmología
AB Aim: This work aimed to design and characterize cross-linked hyaluronic acid–itaconic acid films loaded with acetazolamide–hydroxypropyl β cyclodextrin–triethanolamine complexes. Materials & methods: Films were cross-linked with itaconic acid and poly(ethyleneglycol)-diglycidylether. Biopharmaceutical properties were assessed by evaluating in vitro drug release rate, biocompatibility in a human corneal epithelial cell line, bioadhesiveness with pig gastric mucin, in vivo bioadhesion and efficacy. Results: Showed good mechanical properties and oxygen permeability. Proliferation rate of corneal cells was affected by highest acetazolamide concentration. Bioadhesive interaction exhibited a water movement from pig mucin to the film; in vivo experiments showed strong bioadhesion for 8 h and hypotensive effect for almost 20 h. Conclusion: Experimental set showed promising performance and encouraged future studies to optimize formulation.
PB Newlands Press
SN 2041-5990
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/64907
UL https://uvadoc.uva.es/handle/10324/64907
LA eng
NO Therapeutic Delivery, 2018, vol. 9, n. 3, p. 205-220
NO Producción Científica
DS UVaDOC
RD 28-dic-2024