RT info:eu-repo/semantics/article
T1 Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
A1 Domingo Relloso, Arce
A1 Grau-Perez, Maria
A1 Galan-Chilet, Inmaculada
A1 Garrido-Martinez, Maria J.
A1 Tormos, Carmen
A1 Navas-Acien, Ana
A1 Gomez-Ariza, Jose L.
A1 Monzo-Beltran, Lidia
A1 Saez Tormo, Guillermo
A1 Garcia-Barrera, Tamara
A1 Dueñas Laita, Antonio
A1 Briongos Figuero, Laisa S.
A1 Chaves, F. Javier
A1 Redon, Josep
A1 Tellez Plaza, Maria
A1 Martín Escudero, Juan Carlos
K1 Urine metals, Oxidative stress, Metal mixtures, Population-based
AB Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population.Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study).Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants.Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03–1.27) for Mo, 1.17 (1.05–1.31) for Ba, 1.23 (1.04–1.46) for Cr and 1.18 (1.00–1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03–1.24) for Zn and 1.12 (1.02–1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01–1.23) for Zn and 1.09 (0.99–1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/ GSH but inverse for MDA.Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
PB Pergamon-Elsevier Science LTD, USA
SN 0160-4120
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/64964
UL https://uvadoc.uva.es/handle/10324/64964
LA eng
NO Environment International, febrero 2019, 123, 171-80
DS UVaDOC
RD 12-jul-2024