RT info:eu-repo/semantics/article
T1 High miR-126-3p levels associated with cardiovascular events in a general population
A1 Martínez Arroyo, Olga
A1 Ortega, Ana
A1 Flores Chova, Ana
A1 Sánchez García, Belén
A1 García García, Ana Bárbara
A1 Chaves, Felipe Javier
A1 Forner, María José
A1 Redón Mas, Josep
A1 Cortes, Raquel
A1 Martín Escudero, Juan Carlos
K1 Endothelial dysfunction. Cardiovascular risk. Cardiovascular event. Albuminuria. MicroRNA Biomarker.
AB Background: Endothelial dysfunction is a forerunner of atherosclerosis, leading to cardiovascular disease, and albuminuria is a marker of endothelial dysfunction. Circulating levels of microRNAs are emerging as potential biomarkers for cardiovascular disease. Here we estimate the predictive value of a plasma microRNAs signature associated with albuminuria in the incidence of cardiovascular events.Methods: Plasma microRNAs quantified in hypertensive patients by next generation sequencing were validated in a cohort of patients and controls by real-time quantitative PCR. The microRNAs found to be associated with albuminuria were analysed for their prognostic value in predicting cardiovascular events incidence on a retrospective, population-based study (Hortega Study), using Cox proportional hazard models.Results: A plasma microRNA profile was identified in the discovery cohort (n = 48) associated with albuminuria and three microRNAs (miR-126–3p, miR-1260b and miR-374a-5p) were confirmed in the validation cohort (n = 98). The microRNA signature discriminates urinary albumin excretion at baseline (n = 1025), and predicts the incidence of cardiovascular events and coronary heart disease and stroke in a general population retrospective study within a 14-year follow-up (n = 926). High miR-126–3p levels were associated with a shorter time free of both cardiovascular events (HR=1.48, (1.36–1.62), p < 0.0001), as well as coronary artery disease and stroke combined (HR=2.49, (2.19–2.83), p < 0.0001).Conclusions: An increased plasma microRNAs profile was identified in hypertensive patients with albuminuria. Increased miR-126–3p suggest it may serve as a prognostic marker for cardiovascular events in a long-term general population. Further studies will assess the potential role of miR-126–3p as a guide for the status of endothelial dysfunction.
PB ELSEVIER Scince BV
SN 0953-6205
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/64979
UL https://uvadoc.uva.es/handle/10324/64979
LA eng
NO European Journal of Internal Medicine, Abril 2023, vol. 113, p. 49-56
NO Producción Científica
DS UVaDOC
RD 04-abr-2025