RT info:eu-repo/semantics/article
T1 Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain
A1 Delgado-Velandia, Mario
A1 Gonzalez-Marrachelli, Vannina
A1 Domingo Relloso, Arce
A1 Galvez Fernandez, Marta
A1 Grau-Perez, Maria
A1 Olmedo, Pablo
A1 Galan, Iñaki
A1 Rodriguez-Artalejo, Fernando
A1 Amigo, Nuria
A1 Briongos Figuero, Laisa Socorro
A1 Redon, Josep
A1 Martín Escudero, Juan Carlos
A1 Monleon Salvado, Daniel
A1 Tellez Plaza, Maria
A1 Sotos-Prieto, Mercedes
K1 Cohort study, Healthy lifestyle, Metabolomics, Spanish population, Type 2 diabetes
AB Background: The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes.Methods: A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001–2003, and were followed-up to 2015 to ascertain incident type 2 diabetes.Results: The HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and − 8.23 (95% CI, − 16.34, − 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes.Conclusions: The HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis.
PB BMC
SN 1479-5868
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/64980
UL https://uvadoc.uva.es/handle/10324/64980
LA eng
NO International Journal of Behavioral Nutrition and Physical Activity, Enero 2022, vol.19 n.8,  p.1-13
NO Producción Científica
DS UVaDOC
RD 24-nov-2024