RT info:eu-repo/semantics/article
T1 Embryonic Cerebrospinal Fluid Increases Neurogenic Activity in the Brain Ventricular-Subventricular Zone of Adult Mice
A1 Alonso, MAria Isabel
A1 Lamus, Francisco
A1 Carnicero, Estela
A1 Moro, José Antonio
A1 de  la Mano, Aníbal
A1 Fernández, José María F
A1 Desmond, Mary E
A1 Gato, Ángel
K1 Neurorregeneración
K1 Embriología
K1 brain; brain development; embryonic cerebrospinal fluid (CSF); neural stem cells; neurogenesis; stem-cells; ventricular-subventricular zone (SVZ)
AB Neurogenesis is a very intensive process during early embryonic brain development, becoming dramatically restricted in the adult brain in terms of extension and intensity. We have previously demonstrated the key role of embryonic cerebrospinal fluid (CSF) in developing brain neurogenic activity. We also showed that cultured adult brain neural stem cells (NSCs) remain competent when responding to the neurogenic influence of embryonic CSF. However, adult CSF loses its neurogenic inductive properties. Here, by means of an organotypic culture of adult mouse brain sections, we show that local administration of embryonic CSF in the subventricular zone (SVZ) niche is able to trigger a neurogenic program in NSCs. This leads to a significant increase in the number of non-differentiated NSCs, and also in the number of new neurons which show normal migration, differentiation and maturation. These new data reveal that embryonic CSF activates adult brain NSCs, supporting the previous idea that it contains key instructive components which could be useful in adult brain neuroregenerative strategies.
PB Lausanne: Frontiers Media S.A
SN 1662-5129
YR 2017
FD 2017
LK https://uvadoc.uva.es/handle/10324/65004
UL https://uvadoc.uva.es/handle/10324/65004
LA eng
NO Alonso MI, Lamus F, Carnicero E, Moro JA, de la Mano A, Fernández JMF, Desmond ME, Gato A. Embryonic Cerebrospinal Fluid Increases Neurogenic Activity in the Brain Ventricular-Subventricular Zone of Adult Mice. Front Neuroanat. 2017 Dec 19;11:124
NO Producción Científica
DS UVaDOC
RD 14-oct-2024