RT info:eu-repo/semantics/article
T1 Embryonic cerebrospinal fluid activates neurogenesis of neural precursors within the subventricular zone of the adult mouse brain
A1 Carnicero, Estela
A1 Alonso, Maia Isabel
A1 Carretero, Raquel
A1 Lamus, Francisco
A1 Moro, José Antonio
A1 de  la Mano, Aníbal
A1 Fernández, José María F
A1 Gato, Ángel
K1 Neurorregeneración
K1 Embriología
K1 Animals; Brain; Cell Differentiation; Cell Growth Processes; Cerebral Cortex; Cerebrospinal Fluid; Mice; Neurogenesis; Neurons
AB Introduction: There is a nondeveloped neurogenic potential in the adult mammalian brain, which could be the basis for neuroregenerative strategies. Many research efforts have been made to understand the control mechanisms which regulate the transition from a neural precursor to a neuron in the adult brain. Embryonic cerebrospinal fluid (CSF) is a complex fluid which has been shown to play a key role in neural precursor behavior during development, working as a powerful neurogenic inductor. We tested if the neurogenic properties of embryonic CSF are able to increase the neurogenic activity of neuronal precursors from the subventricular zone (SVZ) in the brains of adult mice.Results: Our results show that mouse embryonic CSF significantly increases the neurogenic activity in precursor cells from adult brain SVZ. This intense neurogenic effect was specific for embryonic CSF and was not induced by adult CSF.Conclusions: Embryonic CSF is a powerful neurogenesis inductor in homologous neuronal precursors in the adult brain. This property of embryonic CSF could be a useful tool in neuroregeneration strategies.
PB Karger
SN 1422-6421; 1422-6405
YR 2014
FD 2014
LK https://uvadoc.uva.es/handle/10324/65028
UL https://uvadoc.uva.es/handle/10324/65028
LA eng
NO Carnicero E, Alonso MI, Carretero R, Lamus F, Moro JA, de la Mano A, Fernández JM, Gato A. Embryonic cerebrospinal fluid activates neurogenesis of neural precursors within the subventricular zone of the adult mouse brain. Cells Tissues Organs. 2013;198(5):398-404
NO Producción Científica
DS UVaDOC
RD 06-ago-2024