RT info:eu-repo/semantics/article
T1 Palladium mono-N-protected amino acid complexes: experimental validation of the ligand cooperation model in C–H activation
A1 Fernández-Moyano, Sara
A1 Salamanca, Vanesa
A1 Albéniz, Ana C.
K1 Química
K1 Catálisis
K1 Activación C-H
K1 Cooperación metal-ligando
K1 Paladio
K1 23 Química
AB Mechanistic proposals for the C–H activation reaction enabled by mono-N-protected amino acid ligands (MPAAs) have been supported by DFT calculations. The direct experimental observation of the ligand- assisted C–H activation has not yet been reported due to the lack of well-defined isolated palladium complexes with MPAAs that can serve as models. In this work, palladium complexes bearing chelating MPAAs (NBu4)[Pd(k2-N,O–AcN–CHR–COO)(C6F5)py] (Ac = MeC(O); R = H, Me) and [Pd(k2-N,O–MeNH– CH2–COO)(C6F5)py] have been isolated and characterized. Their evolution in a solution containing toluene leads to the C–H activation of the arene and the formation of the C6F5–C6H4Me coupling products. This process takes place only for the ligands with an acyl protecting group, showing the cooperating role of this group in a complex with a chelating MPAA, therefore experimentally validating this working model. The carboxylate group is inefficient in this C–H activation.
PB Royal Society of Chemistry
SN 2041-6520
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/65047
UL https://uvadoc.uva.es/handle/10324/65047
LA spa
NO Chem. Sci., 2023, 14, 6688–6694
NO Producción Científica
DS UVaDOC
RD 11-jul-2024