RT info:eu-repo/semantics/article
T1 Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk
A1 Pastor Idoate, Salvador
AB AbstractPurpose: Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD.Methods: We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis.Results: Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82-1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76-1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD.Conclusions: The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility.
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/65108
UL https://uvadoc.uva.es/handle/10324/65108
LA eng
NO Usategui-Martín R, Pastor-Idoate S, Chamorro AJ, Fernández I, Fernández-Bueno I, Marcos-Martín M, González-Sarmiento R, Carlos Pastor J. Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. PLoS One. 2019 Mar 7;14(3):e0213624. doi: 10.1371/journal.pone.0213624. PMID: 30845235; PMCID: PMC6405106.
DS UVaDOC
RD 17-jul-2024