RT info:eu-repo/semantics/article
T1 BAX and BCL‐2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project
A1 Pastor Idoate, Salvador
A1 Rodríguez‐Hernández, Irene
A1 Rojas, Jimena
A1 Fernández, Itziar
A1 García‐Gutierrez, María‐Teresa
A1 Ruiz‐Moreno, Jose M.
A1 Rocha‐Sousa, Amandio
A1 Ramkissoon, Yashin D.
A1 Harsum, Steven
A1 MacLaren, Robert E.
A1 Charteris, David G.
A1 Van Meurs, Jan C.
A1 González‐Sarmiento, Rogelio
A1 Pastor Jimeno, José Carlos
AB AbstractPurpose: To compare the distribution of BCL-2 -938C>A (rs2279115) and BAX -248G>A (rs4645878) genotypes among European subjects undergoing rhegmatogenous retinal detachment (RRD) surgery in relation to the further development of proliferative vitreoretinopathy (PVR).Methods: A case-control gene association study, as a part of Retina 4 project, was designed. rs2279115 and rs4645878 polymorphisms were analysed in 555 samples from patients with RRD (134 with PVR secondary to surgery). Proportions of genotypes and AA homozygous groups of BCL-2 and BAX polymorphisms between subsamples were analysed in two phases. Genotypic and allelic frequencies were compared in global sample and in subsamples.Results: BAX: Differences were observed in the genotype frequencies and in AA carriers between controls and cases in the global series. The odds ratio (OR) of A carriers in the global sample was 1.7 (95% CI: 1.23-2.51). Proportions of genotypes in Spain + Portugal were significant different. The OR of A carriers from Spain and Portugal was 1.8 (95% CI: 1.11-2.95). BCL-2: No significant differences were observed in genotype frequencies. However, proportions of genotypes in Spain + Portugal were significant. A protective effect (OR: 0.6 95% CI: 0.43-0.96) was found in A carriers from Spain and Portugal.Conclusions: Results suggest that A allele of rs4645878 could be a biomarker of high risk of developing PVR in patients undergoing RD surgery. The possible role of BCL-2 (inhibitor of necroptosis pathway) as a possible new target in PVR prophylaxis should be investigated.Keywords: Bcl-2; apoptosis; bax; necroptosis; proliferative vitreoretinopathy; retinal detachment.
SN 1755-375X
YR 2015
FD 2015
LK https://uvadoc.uva.es/handle/10324/65116
UL https://uvadoc.uva.es/handle/10324/65116
LA eng
NO Pastor-Idoate S, Rodríguez-Hernández I, Rojas J, Fernández I, García-Gutierrez MT, Ruiz-Moreno JM, Rocha-Sousa A, Ramkissoon YD, Harsum S, MacLaren RE, Charteris DG, Van Meurs JC, González-Sarmiento R, Pastor JC; Genetics on PVR Study Group. BAX and BCL-2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project. Acta Ophthalmol. 2015 Nov;93(7):e541-9. doi: 10.1111/aos.12718. Epub 2015 May 19. PMID: 25991504.
NO Producción Científica
DS UVaDOC
RD 12-sep-2024