RT info:eu-repo/semantics/article
T1 The secret life of ion channels: Kv1.3 potassium channels and proliferation
A1 Pérez García, María Teresa
A1 Cidad Velasco, María del Pilar
A1 López López, José Ramón
AB Kv1.3 channels are involved in the switch to proliferation of normally quiescent cells, being implicated in the control of cell cycle in many different cell types and in many different ways. They modulate membrane potential controlling K + fluxes, sense changes in potential, and interact with many signaling molecules through their intracellular domains. From a mechanistic point of view, we can describe the role of Kv1.3 channels in proliferation with at least three different models. In the “membrane potential model,” membrane hyperpolarization resulting from Kv1.3 activation provides the driving force for Ca 2+ influx required to activate Ca 2+ -dependent transcription. This model explains most of the data obtained from several cells from the immune system. In the “voltage sensor model,” Kv1.3 channels serve mainly as sensors that transduce electrical signals into biochemical cascades, independently of their effect on membrane potential. Kv1.3-dependent proliferation of vascular smooth muscle cells (VSMCs) could fit this model. Finally, in the “channelosome balance model,” the master switch determining proliferation may be related to the control of the Kv1.3 to Kv1.5 ratio, as described in glial cells and also in VSMCs. Since the three mechanisms cannot function independently, these models are obviously not exclusive. Nevertheless, they could be exploited differentially in different cells and tissues. This large functional flexibility of Kv1.3 channels surely gives a new perspective on their functions beyond their elementary role as ion channels, although a conclusive picture of the mechanisms involved in Kv1.3 signaling to proliferation is yet to be reached.
SN 0363-6143
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/65340
UL https://uvadoc.uva.es/handle/10324/65340
LA spa
NO American Journal of Physiology-Cell Physiology 2018 314:1, C27-C42
DS UVaDOC
RD 04-dic-2024