RT info:eu-repo/semantics/article
T1 Kv channels and vascular smooth muscle cell proliferation
A1 López López, José Ramón
A1 Cidad Velasco, María del Pilar
A1 Pérez García, María Teresa
AB Kv channels are present in virtually all VSMCs and strongly influence contractile responses. However, they are also instrumental in the proliferative, migratory, and secretory functions of synthetic, dedifferentiated VSMCs upon PM. In fact, Kv channels not only contribute to all these processes but also are active players in the phenotypic switch itself. This review is focused on the role(s) of Kv channels in VSMC proliferation, which is one of the best characterized functions of dedifferentiated VSMCs. VSMC proliferation is a complex process requiring specific Kv channels at specific time and locations. Their identification is further complicated by their large diversity and the differences in expression across vascular beds. Of interest, both conserved changes in some Kv channels and vascular bed-specific regulation of others seem to coexist and participate in VSMC proliferation through complementary mechanisms. Such a system will add flexibility to the process while providing the required robustness to preserve this fundamental cellular response.
SN 1073-9688
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/65379
UL https://uvadoc.uva.es/handle/10324/65379
LA spa
NO Microcirculation. 2018; 25:e12427. https://doi.org/10.1111/micc.12427
DS UVaDOC
RD 17-jul-2024