RT info:eu-repo/semantics/article
T1 A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum
A1 Pérez Márquez, Lidia A.
A1 Perretti, Marcelle D.
A1 García Rodríguez, Raúl
A1 Lahoz, Fernando
A1 Carrillo, Romen
K1 Química inorgánica
K1 Molecular Cages
K1 lecular Recognition
K1 Nitrotyrosine
K1 Sensors Tetraphenylethene
K1 2301.06 Fluorimetría
K1 2301 Química Analítica
AB 3-Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen species (RNS), and as a consequence it is accumulated in inflammation-associated conditions. This is particularly relevant in kidney disease, where NT concentration in blood is considerably high. Therefore, NT is a crucial biomarker of renal damage, although it has been underestimated in clinical diagnosis due to the lack of an appropriate sensing method. Herein we report the first fluorescent supramolecular sensor for such a relevant compound: Fluorescence by rotational restriction of tetraphenylethenes (TPE) in a covalent cage is selectively quenched in human blood serum by 3-nitrotyrosine (NT) that binds to the cage with high affinity, allowing a limit of detection within the reported physiological concentrations of NT in chronic kidney disease.
PB Wiley
SN 1433-7851
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/65522
UL https://uvadoc.uva.es/handle/10324/65522
LA eng
NO Angew. Chem. Int. Ed. 2022, 61, e202205403; Angew. Chem. 2022, 134, e202205403
DS UVaDOC
RD 22-nov-2024