RT info:eu-repo/semantics/article
T1 Increased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apnea
A1 Barceló, Antonia
A1 Peña, Mónica de la
A1 Ayllón, Olga
A1 Vega Agapito, María Victoria
A1 Piérola, Javier
A1 Pérez, Gerardo
A1 González, Constancio
A1 Alonso, Alberto
A1 Agustí, Alvar GN
K1 Sleep apnea, Biomarkers, Endothelial dysfunction, Atherosclerosis, Obesity
AB Cardiovascular (CV) diseases are a leadingcause of mortality and they are frequent in patients with theobstructive sleep apnea syndrome (OSAS). Objectives: Inthis study we investigated if OSAS influences CV functionindependently of other CV risk factors frequently present inthese patients (e.g. obesity, high blood pressure). Methods:We compared plasma markers of endothelial dysfunction,asymmetric dimethylarginine (ADMA) and endothelin-1 (ET-1), and atherosclerosis progression (soluble fraction of theCD40 ligand, sCD40L) in OSAS patients with (n = 23) andwithout (n = 18) concurrent CV risk factors, as well as inhealthy subjects (n = 23). Results: Plasma ADMA (p ! 0.01)and sCD40L (p ! 0.05) were abnormally increased in patientswith OSAS versus healthy controls, but they were not influencedby the presence or absence of CV risk factors in OSAS.ET-1 levels were not different between the three groups ofsubjects studied. Conclusions: OSAS is associated with endothelialinjury and atherosclerosis progression independentlyof other CV risk factors.
PB Karger
YR 2009
FD 2009-10
LK https://uvadoc.uva.es/handle/10324/65609
UL https://uvadoc.uva.es/handle/10324/65609
LA eng
NO Respiration, octubre 2009, vol. 77, p.85-90
NO Producción Científica
DS UVaDOC
RD 05-feb-2025