RT info:eu-repo/semantics/article
T1 Increased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apnea
A1 Barceló, Antonia
A1 De la Peña, Mónica
A1 Ayllón, Olga
A1 Vega-Agapito, M Victoria
A1 Piérola, Javier
A1 Pérez, Gerardo
A1 González, Constancio
A1 Alonso, Alberto
A1 Agustí, Alvar GN
K1 Sleep apnea, Biomarkers, Endothelial dysfunction, Atherosclerosis, Obesity
AB Cardiovascular (CV) diseases are a leadingcause of mortality and they are frequent in patients with theobstructive sleep apnea syndrome (OSAS). Objectives: Inthis study we investigated if OSAS influences CV functionindependently of other CV risk factors frequently present inthese patients (e.g. obesity, high blood pressure). Methods:We compared plasma markers of endothelial dysfunction,asymmetric dimethylarginine (ADMA) and endothelin-1 (ET-1), and atherosclerosis progression (soluble fraction of theCD40 ligand, sCD40L) in OSAS patients with (n = 23) andwithout (n = 18) concurrent CV risk factors, as well as inhealthy subjects (n = 23). Results: Plasma ADMA (p ! 0.01)and sCD40L (p ! 0.05) were abnormally increased in patientswith OSAS versus healthy controls, but they were not influencedby the presence or absence of CV risk factors in OSAS.ET-1 levels were not different between the three groups ofsubjects studied. Conclusions: OSAS is associated with endothelialinjury and atherosclerosis progression independentlyof other CV risk factors.
PB Karger
YR 2009
FD 2009-10
LK https://uvadoc.uva.es/handle/10324/65609
UL https://uvadoc.uva.es/handle/10324/65609
LA eng
NO Respiration, octubre 2009, vol. 77, p.85-90
NO Producción Científica
DS UVaDOC
RD 26-dic-2024