RT info:eu-repo/semantics/article
T1 Effects of Intermittent Hypoxia on Blood Gases Plasma Catecholamine and Blood Pressure
A1 González-Martin, MC
A1 Vega-Agapito, V
A1 Prieto Lloret, Jesús
A1 Agapito, MT
A1 Castañeda, J
A1 Gonzalez, C
K1 Obstructive sleep apnoea · Intermittent hypoxia · Blood gases · Plasma norepinephrine · Arterial blood pressure · HbO2 saturation
AB Obstructive sleep apnoea syndrome (OSAS) is a disorder characterizedby repetitive episodes of complete (apnoea) or partial (hypopnoea) obstructionof airflow during sleep. The severity of OSAS is defined by the apnoea hypopnoeaindex (AHI) or number of obstructive episodes. An AHI greater than 30 isconsidered severe, but it can reach values higher than 100 in some patients. Associatedto the OSA there is high incidence of cardiovascular and neuro-psychiatricpathologies including systemic hypertension, stroke, cardiac arrhythmias andatherosclerosis, diurnal somnolence, anxiety and depression. In the present studywe have used a model of intermittent hypoxia (IH) of moderately high intensity(30 episodes/h) to evaluate arterial blood gases and plasma catecholamines as maineffectors in determining arterial blood pressure. Male rats were exposed to IH witha regime of 80s, 20% O2 // 40s, 10%O2, 8 h/day, 8 or 15 days.Lowering the breathing atmosphere to 10% O2 reduced arterial blood PO2 to56.9mmHg (nadir HbO2 86, 3%). Plasma epinephrine (E) and norepinephrine (NE)levels at the end of 8 and 15 days of IH showed a tendency to increase, being significantthe increase of norepinephrine (NE) levels in the group exposed to intermittenthypoxia during 15 days. We conclude that IH causes an increase in sympatheticactivity and a concomitant increase in NE levels which in turn would generate anincrease in vascular tone and arterial blood pressure.
PB Springer
YR 2009
FD 2009
LK https://uvadoc.uva.es/handle/10324/65610
UL https://uvadoc.uva.es/handle/10324/65610
LA eng
NO Advances in Experimental Medicine and Biology, 2009, vol. 648, p.319-328
NO Producción Científica
DS UVaDOC
RD 20-oct-2024