RT info:eu-repo/semantics/article
T1 Effects of L-carnitine Intake on exercise-induced muscle damage and oxidative stress: A narrative scoping review
A1 Caballero García, Alberto
A1 Noriega González, David César
A1 Roche Collado, Enrique
A1 Drobnic, Franchek
A1 Córdova Martínez, Alfredo
K1 Aminoácidos
K1 Muscle damage
K1 Muscles - Diseases
K1 Músculos - Enfermedades
K1 Oxidative stress
K1 Estrés oxidativo
K1 Nutrition
K1 Supplementation
K1 Dietary supplements
K1 Suplementos nutritivos
K1 L-carnitine
K1 3206 Ciencias de la Nutrición
K1 32 Ciencias Médicas
AB Exercise-induced muscle damage results in decreased physical performance that is accompanied by an inflammatory response in muscle tissue. The inflammation process occurs with the infiltration of phagocytes (neutrophils and macrophages) that play a key role in the repair and regeneration of muscle tissue. In this context, high intensity or long-lasting exercise results in the breakdown of cell structures. The removal of cellular debris is performed by infiltrated phagocytes, but with the release of free radicals as collateral products. L-carnitine is a key metabolite in cellular energy metabolism, but at the same time, it exerts antioxidant actions in the neuromuscular system. L-carnitine eliminates reactive oxygen and nitrogen species that, in excess, alter DNA, lipids and proteins, disturbing cell function. Supplementation using L-carnitine results in an increase in serum L-carnitine levels that correlates positively with the decrease in cell alterations induced by oxidative stress situations, such as hypoxia. The present narrative scoping review focuses on the critical evaluation of the efficacy of L-carnitine supplementation on exercise-induced muscle damage, particularly in postexercise inflammatory and oxidative damage. Although both concepts appear associated, only in two studies were evaluated together. In addition, other studies explored the effect of L-carnitine in perception of fatigue and delayed onset of muscle soreness. In view of the studies analyzed and considering the role of L-carnitine in muscle bioenergetics and its antioxidant potential, this supplement could help in postexercise recovery. However, further studies are needed to conclusively clarify the mechanisms underlying these protective effects.
PB MDPI
SN 2072-6643
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/65770
UL https://uvadoc.uva.es/handle/10324/65770
LA eng
NO Nutrients, 2023, Vol. 15, Nº. 11, 2587
NO Producción Científica
DS UVaDOC
RD 11-jul-2024