RT info:eu-repo/semantics/article
T1 Exact model reduction with delays: closed-form distributions and extensions to fully bi-directional monomolecular reactions
A1 Leier, Andre
A1 Barrio, Manuel
A1 Marquez-Lago, Tatiana T.
AB In order to systematically understand the qualitative and quantitative behaviour of chemical reaction networks, scientists must derive and analyse associated mathematical models. However, biochemical systems are often very large, with reactions occurring at multiple time scales, as evidenced by signalling pathways and gene expression kinetics. Owing to the associated computational costs, it is then many times impractical, if not impossible, to solve or simulate these systems with an appropriate level of detail. By consequence, there is a growing interest in developing techniques for the simplification or reduction of complex biochemical systems. Here, we extend our recently presented methodology on exact reduction of linear chains of reactions with delay distributions in two ways. First, we report that it is now possible to deal with fully bi-directional monomolecular systems, including degradations, synthesis and …
PB The Royal Society
SN 1742-5689
YR 2014
FD 2014
LK https://uvadoc.uva.es/handle/10324/65827
UL https://uvadoc.uva.es/handle/10324/65827
LA spa
NO Journal of The Royal Society Interface, Volume 11, Issue 95, Pages 20140108
DS UVaDOC
RD 11-jul-2024