RT info:eu-repo/semantics/article
T1 Effects of cigarette smoke and chronic hypoxia on airways remodeling and resistance. Clinical significance
A1 Olea Fraile, Elena
A1 Ferrer, Elisabet
A1 Prieto Lloret, Jesús
A1 Gonzalez-Martin, Carmen
A1 Vega-Agapito, Victoria
A1 Gonzalez-Obeso, Elvira
A1 Agapito, Teresa
A1 Peinado, Victor
A1 Obeso, Ana
A1 Barbera, Joan Albert
A1 Gonzalez, Constancio
K1 Guinea pig Tobacco smoke Hypoxia Airways remodeling Penh
AB Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interactpositively to physiopathologically remodel pulmonary circulation. In present study we have exposedguinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O2, 15 days;CH) alone or in combination (CSCH animals) and evaluated airways remodeling and resistance assessedas Penh (enhance pause). We measured Penh while animals breathe air, 10% O2 and 5% CO2 and foundthat CS and CH animals have higher Penh than controls; Penh was even larger in CSCH animals. A roughparallelism between Penh and thickness of bronchiolar wall and muscular layer and Goblet cell numberwas noticed. We conclude that CS and CH association accelerates CS-induced respiratory system damage,evidenced by augmented airway resistance, bronchial wall thickness and muscularization and Gobletcell number. Our findings would suggest that appearance of hypoxia would aggravate any preexistingpulmonary pathology by increasing airways resistance and reactivity.
PB Elsevier
SN 1569-9048
YR 2011
FD 2011
LK https://uvadoc.uva.es/handle/10324/65863
UL https://uvadoc.uva.es/handle/10324/65863
LA eng
NO Respiratory Physiology and Neurobiology, 2011, 179, p.305-313
NO Producción Científica
DS UVaDOC
RD 28-sep-2024