RT info:eu-repo/semantics/article
T1 Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance
A1 Olea Fraile, Elena
A1 Ferrer, Elisabet
A1 Prieto Lloret, Jesús
A1 Gonzalez-Martin, Carmen
A1 Vega-Agapito, Victoria
A1 Gonzalez-Obeso, Elvira
A1 Agapito, Teresa
A1 Peinado, Victor
A1 Obeso, Ana
A1 Barbera, Joan Albert
A1 Gonzalez, Constancio
K1 Guinea pig • Ventilation • Tobacco • Hypoxia • Carotid body
AB Ventilatory effects of chronic cigarette smoke (CS) alone or associated to chronic hypoxia(CH), as frequently occurs in chronic obstructive pulmonary disease (COPD), remain unknown. Wehave addressed this problem using whole-body plethysmography in guinea-pigs, common models tostudy harmful effects of CS on the respiratory system. Breathing frequencies (Bf) in control(2–5 months old) guinea pigs is 90–100 breaths/min, their tidal volume (TV) increased with age butlagged behind body weight gain and, as consequence, their minute volume (MV)/Kg decreased withage. MV did not change by acutely breathing 10% O 2 but doubled while breathing 5% CO 2 in air.Exposure to chronic sustained hypoxia (15 days, 12% O 2 , CH) did not elicit ventilatory acclimatizationnor adaptation. These fi ndings con fi rm the unresponsiveness of the guinea pig CB to hypoxia.Exposure to CS (3 months) increased Bf and MV but association with CH blunted CS effects. Weconclude that CS and CH association accelerates CS-induced respiratory system damage leading to ahypoventilation that can worsen the ongoing COPD process.
PB Springer
SN 0065-2598
YR 2012
FD 2012
LK https://uvadoc.uva.es/handle/10324/65866
UL https://uvadoc.uva.es/handle/10324/65866
LA eng
NO Advances in Experimental Medicine and Biology, 2012, vol. 758, p.325-332
NO Producción Científica
DS UVaDOC
RD 28-nov-2024