RT info:eu-repo/semantics/article
T1 Quantification of microvascular lesions in the central retinal field: Could It predict the severity of diabetic retinopathy?
A1 Fernández Carneado, Jimena
A1 Almazán Moga, Ana
A1 Ramírez Lamelas, Dolores T.
A1 Cuscó, Cristina
A1 Alonso de la Fuente, José Ignacio
A1 Pastor Jimeno, José Carlos
A1 López Gálvez, María Isabel
A1 Ponsati, Berta
K1 Diabetic retinopathy
K1 Retinopatía diabética
K1 Eye - Diseases
K1 Ojo - Enfermedades y defectos
K1 Diabetes - Complicaciones y secuelas
K1 Ophthalmology
K1 Microvascular
K1 Clinical utility
K1 Medical Research
K1 Clinical medicine
K1 Medicina clínica - Investigación
K1 Public health
K1 3201.09 Oftalmología
K1 32 Ciencias Médicas
K1 3212 Salud Publica
AB Diabetic retinopathy (DR) is a neurodegenerative disease characterized by the presence of microcirculatory lesions. Among them, microaneurysms (MAs) are the first observable hallmark of early ophthalmological changes. The present work aims to study whether the quantification of MAs, hemorrhages (Hmas) and hard exudates (HEs) in the central retinal field could have a predictive value on DR severity. These retinal lesions were quantified in a single field NM-1 of 160 retinographies of diabetic patients from the IOBA’s reading center. Samples included different disease severity levels and excluded proliferating forms: no DR (n = 30), mild non-proliferative (n = 30), moderate (n = 50) and severe (n = 50). Quantification of MAs, Hmas, and HEs revealed an increasing trend as DR severity progresses. Differences between severity levels were statistically significant, suggesting that the analysis of the central field provides valuable information on severity level and could be used as a clinical tool to assess DR grading in the eyecare routine. Even though further validation is needed, counting microvascular lesions in a single retinal field can be proposed as a rapid screening system to classify DR patients with different stages of severity according to the international classification.
PB MDPI
SN 2077-0383
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/65876
UL https://uvadoc.uva.es/handle/10324/65876
LA eng
NO Journal of Clinical Medicine, 2023, Vol. 12, Nº. 12, 3948
NO Producción Científica
DS UVaDOC
RD 17-jul-2024