RT info:eu-repo/semantics/article
T1 Calcium uptake mechanisms of mitochondria
A1 Demaurex, Nicolas
A1 Santo-Domingo, Jaime
K1 calcium
K1 mitochondria
AB The ability of mitochondria to capture Ca2+ ions has important functional implications for cells, because mitochondria shape cellular Ca2+ signals by acting as a Ca2+ buffer and respond to Ca2+ elevations either by increasing the cell energy supply or by triggering the cell death program of apoptosis. A mitochondrial Ca2+ channel known as the uniporter drives the rapid and massive entry of Ca2+ ions into mitochondria. The uniporter operates at high, micromolar cytosolic Ca2+ concentrations that are only reached transiently in cells, near Ca2+ release channels. Mitochondria can also take up Ca2+ at low, nanomolar concentrations, but this high affinity mode of Ca2+ uptake is not well characterized. Recently, leucine-zipper-EF hand-containing transmembrane region (Letm1) was proposed to be an electrogenic 1:1 mitochondrial Ca2+/H+ antiporter that drives the uptake of Ca2+ into mitochondria at nanomolar cytosolic Ca2+ concentrations. In this article, we will review the properties of the Ca2+ import systems of mitochondria and discuss how Ca2+ uptake via an electrogenic 1:1 Ca2+/H+ antiport challenges our current thinking of the mitochondrial Ca2+ uptake mechanism.
PB Elsevier
SN 0005-2728
YR 2010
FD 2010
LK https://uvadoc.uva.es/handle/10324/65919
UL https://uvadoc.uva.es/handle/10324/65919
LA spa
NO Biochim Biophys Acta, Junio 2010, vol 1797, n. 6-7, p. 907-12.
DS UVaDOC
RD 29-nov-2024