RT info:eu-repo/semantics/article
T1 Multicomponent Prins Cyclization from Allylsilyl Alcohols Leading to Dioxaspirodecanes
A1 Barbero Pérez, María Asunción
A1 Diez de la Varga, Alberto
A1 Pulido Pelaz, Francisco José
AB A multicomponent reaction for the preparation of dioxaspirodecanes starting from allylsilyl alcohols was achieved. The one-pot sequence involves the sequential acid-catalyzed reaction of an allylsilyl alcohol with an aldehyde to afford an alkenediol. The subsequent Prins cyclization of the homoallylic alcohol moiety generates a tetrahydropyranyl carbocation which is intramolecularly trapped by the second hydroxyl group. The chemoselectivity of the process shows dependence on the nature of the aldehyde and the concentration of the catalyst.
PB American Chemical Society
SN 1523-7060
YR 2013
FD 2013
LK https://uvadoc.uva.es/handle/10324/65951
UL https://uvadoc.uva.es/handle/10324/65951
LA eng
NO Org. Lett. 2013, 15, 20, 5234–5237
NO Producción Científica
DS UVaDOC
RD 23-dic-2024