RT info:eu-repo/semantics/article
T1 Unveiling the Neutral Forms of Glutamine
A1 León Ona, Iker
A1 Alonso Alonso, Elena Rita
A1 Mata López, Santiago
A1 Cabezas, Carlos
A1 Alonso Hernández, José Luis
K1 amino acid · FTMW spectroscopy · glutamine ·non-covalent interactions · rotational spectroscopy
AB Neutral glutamine has been evaporated by laserablation of its solid sample to seed a rare gas carrier prior toa supersonic expansion and proved by Fourier transformmicrowave techniques. We report on three distinct neutralconformers that show a singular non-interacting and flexibleamide sidechain in contrast with the other proteinogenicaliphatic amino acids. It could explain the essential biologicalrole of glutamine as a nitrogen source, and its unique ability toform a variety of hydrogen bonds with peptide backbones.Common computational methods fail to predict the delicatebalance of intramolecular interactions controlling the geome-try of the most stable conformer. The spectroscopic data herereported can be used to benchmark novel computationalmethods in quantum chemistry.
PB WILEY-V C H VERLAG GMBH
SN 1433-7851
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/65992
UL https://uvadoc.uva.es/handle/10324/65992
LA spa
NO Angewandte Chemie International Edition, 2019, 58, 16002
NO Producción Científica
DS UVaDOC
RD 03-abr-2025