RT info:eu-repo/semantics/article
T1 Unveiling the Neutral Forms of Glutamine
A1 León, Iker
A1 Alonso, Elena R.
A1 Mata, Santiago
A1 Cabezas, Carlos
A1 Alonso, Jose Luis
K1 amino acid · FTMW spectroscopy · glutamine ·non-covalent interactions · rotational spectroscopy
AB Neutral glutamine has been evaporated by laserablation of its solid sample to seed a rare gas carrier prior toa supersonic expansion and proved by Fourier transformmicrowave techniques. We report on three distinct neutralconformers that show a singular non-interacting and flexibleamide sidechain in contrast with the other proteinogenicaliphatic amino acids. It could explain the essential biologicalrole of glutamine as a nitrogen source, and its unique ability toform a variety of hydrogen bonds with peptide backbones.Common computational methods fail to predict the delicatebalance of intramolecular interactions controlling the geome-try of the most stable conformer. The spectroscopic data herereported can be used to benchmark novel computationalmethods in quantum chemistry.
PB WILEY-V C H VERLAG GMBH
SN 1433-7851
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/65992
UL https://uvadoc.uva.es/handle/10324/65992
LA spa
NO Angewandte Chemie International Edition, 2019, 58, 16002
NO Producción Científica
DS UVaDOC
RD 11-jul-2024