RT info:eu-repo/semantics/article
T1 Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes
A1 De Marchi, Umberto
A1 Fernandez‐Martinez, Silvia
A1 Fuente Pérez, Sergio De La
A1 Wiederkehr, Andreas
A1 Santo Domingo Mayoral, Jaime
K1 mitochondria, ion channels, MCU, calcium, diabetes
AB Pancreatic beta-cells are central regulators of glucose homeostasis. By tightly coupling nutrient sensing and granule exocytosis, beta-cells adjust the secretion of insulin to the circulating blood glucose levels. Failure of beta-cells to augment insulin secretion in insulin-resistant individuals leads progressively to impaired glucose tolerance, Type 2 diabetes, and diabetes-related diseases. Mitochondria play a crucial role in β-cells during nutrient stimulation, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion. Mitochondria are double-membrane organelles containing numerous channels allowing the transport of ions across both membranes. These channels regulate mitochondrial energy production, signaling, and cell death. The mitochondria of β-cells express ion channels whose physio/pathological role is underappreciated. Here, we describe the mitochondrial ion channels identified in pancreatic β-cells, we further discuss the possibility of targeting specific β-cell mitochondrial channels for the treatment of Type 2 diabetes, and we finally highlight the evidence from clinical studies.
PB Wiley
SN 0007-1188
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/66020
UL https://uvadoc.uva.es/handle/10324/66020
LA spa
NO Br J Pharmacol. May 2021. vol. 178, n. 10, p. 2077-2095.
NO Producción Científica
DS UVaDOC
RD 04-abr-2025